The medial prefrontal cortex (mPFC) is essential in the execution of cognitive tasks, however very little is known on how these neurons are modulated during specific tasks and which subtype of neurons are responsible for so. Therego, with the intention of addressing this issue, we recorded mPFC gabaergic...
Abstract Background: Glutamate and voltage-gated sodium channels, both have been the target of intense investigation for its involvement in carcinogenesis and progression of malignant disease. Breast cancer with increased level of glutamate often metastasize to other organs (especially bone), whilst re-e...
Resumen El objetivo del trabajo fue evaluar la asociación entre el nivel de glutamato en el líquido cefalorraquídeo (LCR) al inicio de la enfermedad y la progresión de la enfermedad durante el seguimiento en una cohorte de pacientes con esclerosis múltiple (EM). Se determinaron niveles de glutamato ...
Introducción: El síndrome del hombre rígido representa una rara enfermedad neuromuscular
caracterizada por rigidez muscular progresiva y espasmos musculares dolorosos que afecta a 1
persona por cada millón de habitantes por año en el mundo. En la mayoría de los pacientes se
encuentran niveles eleva...
BACKGROUND: To investigate the thalamic neurotransmitters and functional connections in the development of chronic constriction injury (CCI)-induced neuropathic pain. METHODS: The paw withdrawal threshold was measured by mechanical stimulation the right hind paw with the von frey hair in the rats of CCI-...
Introduction: Three vanadium complexes with orotic and glutamic acids, in their anion forms, were prepared and their in vitro cytotoxicity toward human lung fibroblasts (MRC-5), human hepatocellular carcinoma (HepG2) and human colorectal adenocarcinoma (Caco-2) are reported. Objective: Describe the synth...
Carcinoma Hepatocelular/tratamiento farmacológico,
Compuestos de Vanadio/farmacología,
Ensayos de Selección de Medicamentos Antitumorales,
Técnicas In Vitro,
Ácido Orótico/farmacología,
Ácido Glutámico/farmacología,
Fibroblastos Asociados al Cáncer/efectos de los fármacos,
Neoplasias Pulmonares/tratamiento farmacológico,
Adenocarcinoma/tratamiento farmacológico,
Neoplasias Colorrectales/tratamiento farmacológico,
Antineoplásicos/farmacología,
Línea Celular Tumoral/efectos de los fármacos
Introduction: The etiology of autoimmune diseases is still unknown, but different causes arise. Objective: To describe the role of hormones, diet, stress and infections in the etiology of autoimmune diseases. Methods: A bibliographic review was made using the Google Scholar and articles of free acce...
Studies on toad poison are relevant since they are considered a good source of toxins that act on different biological systems. Among the molecules found in the toad poison, it can be highlighted the cardiotonic heterosides, which have a known mechanism that inhibit Na+/K+-ATPase enzyme. However, these p...
ABSTRACT Clavulanic acid is a β-lactam compound with potent inhibitory activity against β-lactamases. Studies have shown that certain amino acids play essential roles in CA biosynthesis. However, quantitative evaluations of the effects of these amino acids are still needed in order to improve C...
Ácido Clavulánico/biosíntesis,
Medios de Cultivo/química,
Medios de Cultivo/metabolismo,
Ácido Glutámico/análisis,
Ácido Glutámico/metabolismo,
Nitrógeno/análisis,
Nitrógeno/metabolismo,
Ornitina/análisis,
Ornitina/metabolismo,
Streptomyces/genética,
Streptomyces/metabolismo
Lin, Ruhui;
Li, Long;
Zhang, Yingzheng;
Huang, Sheng;
Chen, Shangjie;
Shi, Jiao;
Zhuo, Peiyuan;
Jin, Hao;
Li, Zuanfang;
Liu, Weilin;
Wang, Zhifu;
Chen, Lidian;
Tao, Jing.
OBJECTIVE: To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease. Methods N -Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluate...
Ácido Aspártico/análogos & derivados,
Electroacupuntura/métodos,
Ácido Glutámico/metabolismo,
Hipocampo/química,
Aprendizaje/fisiología,
Memoria/fisiología,
Ácido Aspártico/metabolismo,
Hipocampo/diagnóstico por imagen,
Inositol/análisis,
Glicoproteínas de Membrana/análisis,
Proteínas Tirosina Quinasas/análisis,
Western Blotting,
Factor Neurotrófico Derivado del Encéfalo,
Prueba de Esfuerzo,
Imagen por Resonancia Magnética,
Espectroscopía de Resonancia Magnética,
Aprendizaje por Laberinto,
Ratones Transgénicos,
Modelos Animales,
Distribución Aleatoria
