Adlat, Salah;
Hayel, Farooq;
Yang, Ping;
Chen, Yang;
Mar Oo, Zin;
Zaw Myint, May Zun;
Kumar Sah, Rajiv;
Bahadar, Noor;
Al-Azab, Mahmoud;
Binta Bah, Fatoumata;
Zheng, Yaowu;
Feng, Xuechao.
BACKGROUND: Many human genetic diseases arise from point mutations. These genetic diseases can theoretically be corrected through gene therapy. However, gene therapy in clinical application is still far from mature. Nearly half of the pathogenic single-nucleotide polymorphisms (SNPs) are caused by G:C>A:...
ABSTRACT Objective: To evaluate the accuracy of determining the adenosine deaminase (ADA) level, the 2'-deoxyadenosine/ADA ratio, and the LDH/ADA ratio in pleural fluid for the diagnosis of pleural tuberculosis (PT) in children and adolescents. Methods: This was a retrospective cross-sectional study co...
The conversion of adenosine to inosine is catalyzed by adenosine deaminase (ADA) (EC 3.5.4.4), which has two isoforms in humans (ADA1 and ADA2) and belongs to the zinc-dependent hydrolase family. ADA modulates lymphocyte function and differentiation, and regulates inflammatory and immune responses. This ...
OBJECTIVES: We compared the diagnostic potential of cancer ratio (CR, serum lactate dehydrogenase [LDH]/pleural fluid adenosine deaminase [pfADA]), cancer ratio plus (CR plus, cancer ratio/pleural lymphocyte percentage), and age/pfADA ratio with pfADA in malignant pleural effusion. METHODS: Data from 10...
Skeletal muscle injury is a frequent event and diagnosis using the classical blood markers sometimes produces unsatisfactory results. Therefore, objective of the study was to detect new biomarkers in plasma, saliva and urine in response to acute muscle damage induced by physical exercise. A cross-section...
A entidade nosológica denominada derrame pleural (DP) apresenta mais de 50 etiologias, sendo a insuficiência cardíaca, as neoplasias, a pneumonia e a tuberculose pleural (TBPl) as causas mais frequentes. As dificuldades para se determinar a causa de um DP é uma realidade seja em locais da estrutura b...
Tuberculosis Pleural/diagnóstico,
Derrame Pleural/etiología,
Adenosina Desaminasa/química,
Interferón gamma/química,
Modelos Estadísticos,
Sensibilidad y Especificidad,
Valor Predictivo de las Pruebas,
Citocinas/inmunología,
Quimiocinas/inmunología,
Estudios Transversales/métodos,
Curva ROC,
Análisis Multivariante
Resumen Introducción: La tuberculosis abdominal es un problema reemergente, y es una de las enfermedades transmisibles más importante en todo el mundo. A pesar de las expectativas acerca de su erradicación en países en desarrollo, ha sido recientemente declarada de nuevo como una patología de emerg...
Peritonitis Tuberculosa/cirugía,
Peritonitis Tuberculosa/cirugía,
Tuberculosis Gastrointestinal/cirugía,
Tuberculosis Gastrointestinal/diagnóstico,
Peritonitis Tuberculosa/diagnóstico,
Radiografía Torácica,
Tomografía Computarizada por Rayos X,
Tuberculosis Gastrointestinal/enzimología,
Peritonitis Tuberculosa/enzimología,
Líquido Ascítico/química,
Adenosina Desaminasa/análisis,
Diagnóstico Diferencial
Tuberculosis (TB) is a common cause of pleural effusion in young people from endemic areas. Among the forms of extrapulmonary TB in people with immunodeficiencies, the most frequent localization is the pleura. The use of immunological and molecular biology tests for the diagnosis of TB in pleural fluid a...
La tuberculosis es una enfermedad infecciosa de gran prevalencia en países en vía de desarrollo
como el nuestro. Aunque el compromiso pulmonar es el más frecuente y de impacto
en la salud pública, existen varias formas extrapulmonares con diversas presentaciones
clínicas y de difícil diagnóstico, ...
ABSTRACT Heroin is known to enhance catabolism and inhibit anabolism of purine nucleotides, leading to purine nucleotide deficiencies in rat brains. Here, we determined the effect of exogenous purine nucleotide administration on purine nucleotide metabolism in the brains of heroin-dependent rats. Heroin ...
