Results: 294

Efeito da infecção experimental por Aggregatibacter actinomycetemcomitans e Streptococcus gordonii sobre a expressão de genes associados à barreira intestinal e inflamação, níveis séricos de LPS e reabsorção do osso alveolar em modelo murino
Association of Aggregatibacter actinomycetemcomitans and Streptococcus gordonii for induction of experimental periodontitis in mice

Periodontite é uma doença inflamatória, induzida por uma microbiota disbiótica, que tem sido associada a uma série de condiçoes sistêmicas, como diabetes e doenças cardiovasculares. Aggregatibacter actinomycetemcomitans é o patógeno mais associado à previamente chamada periodontite agressiva, ...

In silico evaluation of the gene expression profile of syndecan-4 in different breast tumor subtypes

ABCS health sci; 49 (), 2024
INTRODUCTION: Breast cancer is one of the main causes of death in women. Luminal tumors A and B show good response with hormonal treatments, tumors that overexpress HER-2 can be treated with monoclonal antibodies, whereas triple negative tumors have few treatments available because they present low or ab...

Improvement of Na+-K+ ATPase Activity and Gene Expression Associated with Glomerular Ultrastructural Protection in Diabetic Nephropathy by Acacia senegal: Role of Oxidative Stress Disturbances

Int. j. morphol; 42 (1), 2024
SUMMARY: This study assessed the effects of Acacia Senegal (AS) combined with insulin on Na+/K+-ATPase (NKA) activity and mRNA expression, serum glucose, renal function, and oxidative stress in a rat model of diabetic nephropathy (DN). Sixty rats were equally divided into six groups: normal control, norm...

Estrogen deficiency influences SEC23A gene expression in the odontogenic region of incisors – a murine model study

Braz. dent. sci; 27 (1), 2024
Recent scientific evidence suggests a close relationship between estrogen deficiency and vitamin D- related genes. Estrogen and vitamin D were involved with alterations in odontogenesis and tooth eruption process. Objective: The aim of the present study was to evaluate the influence of estrogen deficienc...

Nuclear factor kappa-light-chain-enhancer of activated B cells gene expression involvement in porcine liver transplant experimental model

Acta cir. bras; 39 (), 2024
Purpose: Gene expressions of vascular Endothelial Growth Factor Alpha (VEGFa), Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B cells (NFkB) and cytokines could be useful for identifying potential therapeutic targets to alleviate ischemia-reperfusion injury after liver transplantation. Cytokine g...

Efeito do cigarro eletrônico na saliva e no epitélio da mucosa bucal
Effect of electronic cigarettes on saliva and oral mucosal epithelium

A utilização indiscriminada de cigarros eletrônicos (e-cigs) já representa um problema de saúde pública mundial e pouco se sabe quanto aos efeitos de seu uso sobre a saúde bucal. O objetivo deste trabalho foi avaliar o efeito do uso do e-cig na saliva e na mucosa bucal de seus usuários. Foram for...

microRNAs e seus mecanismos de regulação gênica na toxoplasmose gestacional

A toxoplasmose é uma zoonose cosmopolita e quando a infecção ocorre durante a gravidez (toxoplasmose gestacional) o parasita pode atravessar a placenta, causando a forma congênita, e causar danos graves. Investigar como os microRNAs regulam a infecção pode oferecer informações valiosas sobre sua ...

High-intensity interval training (treadmill) effects in myokines and endoplasmic reticulum stress of calf muscles in obese mice

Int. j. morphol; 41 (2), 2023
SUMMARY: Obesity is commonly associated with chronic tissue inflammation and skeletal muscle dysfunction. The study aimed to investigate the effects of High-Intensity Interval training (HIIT) on myokines and endoplasmic reticulum (ER) stress of diet- induced obese (DIO) mice. Three-month-old C57BL/6 male...

Identification of novel biomarkers with potential for diagnosis and prognosis of gastric cancer: a bioinformatics approach

ABCS health sci; 48 (), 2023
INTRODUCTION: Gastric cancer (GC) is the fifth most diagnosed neoplasia and the third leading cause of cancer-related deaths. A substantial number of patients exhibit an advanced GC stage once diagnosed. Therefore, the search for biomarkers contributes to the improvement and development of therapies. OBJ...

Estrogen deficiency influences TNF-α and IL-1β gene expression in the odontogenic region of dental hypofunctional condition

Braz. dent. sci; 26 (2), 2023
Objetivo: Evidências científicas sugerem que a deficiência de estrógeno e fatores genéticos influenciam o desenvolvimento do sistema estomatognático. Este estudo teve como objetivo avaliar a influência da deficiência de estrógeno na expressão gênica de TNF-α, IL-1β, IL-6 e IL-10 durante o de...