Periodontite é uma doença inflamatória, induzida por uma microbiota disbiótica, que tem sido associada a uma série de condiçoes sistêmicas, como diabetes e doenças cardiovasculares. Aggregatibacter actinomycetemcomitans é o patógeno mais associado à previamente chamada periodontite agressiva, ...
INTRODUCTION: Breast cancer is one of the main causes of death in women. Luminal tumors A and B show good response with hormonal treatments, tumors that overexpress HER-2 can be treated with monoclonal antibodies, whereas triple negative tumors have few treatments available because they present low or ab...
Bashir, Salah O;
Morsy, Mohamed D;
Mohammed, Muataz E;
Abbas, Amr M;
Badi, Rehab M;
Osman, Osama M;
Dawood, Amal F;
Saeed, Amal M;
Eid, Refaat A;
Sabir, Deema K.
SUMMARY: This study assessed the effects of Acacia Senegal (AS) combined with insulin on Na+/K+-ATPase (NKA) activity and mRNA expression, serum glucose, renal function, and oxidative stress in a rat model of diabetic nephropathy (DN). Sixty rats were equally divided into six groups: normal control, norm...
Acacia/química,
Extractos Vegetales/administración & dosificación,
Extractos Vegetales/farmacología,
Nefropatías Diabéticas/tratamiento farmacológico,
ATPasa Intercambiadora de Sodio-Potasio/efectos de los fármacos,
ATPasa Intercambiadora de Sodio-Potasio/genética,
Estrés Oxidativo,
Control Glucémico,
Insulina/administración & dosificación,
Quimioterapia Combinada,
Expresión Génica,
Malondialdehído,
Superóxido Dismutasa,
Modelos Animales de Enfermedad,
Ratas Sprague-Dawley,
Riñón/efectos de los fármacos,
Microscopía Electrónica de Transmisión,
Hemoglobina Glucada/análisis,
d0123330
Nascimento, lara Costa do;
Silveira, Marcus Augusto;
Paula, Millena Cristina de;
Taranto, Martinelle Ferreira da Rocha;
Schröder, Agnes;
Kirschneck , Christian;
Nelson-Filho, Paulo;
Lepri, César Penazzo;
Baratto-Filho, Flares;
Küchler, Erika Calvano;
Madalena, Isabela Ribeiro.
Recent scientific evidence suggests a close relationship between estrogen deficiency and vitamin D- related genes. Estrogen and vitamin D were involved with alterations in odontogenesis and tooth eruption process. Objective: The aim of the present study was to evaluate the influence of estrogen deficienc...
Nacif, Lucas Souto;
Galvão, Flávio;
Kubrusly, Márcia Saldanha;
Zanini, Leonardo Yuri Kasputis;
Espinoza, Paola;
Waisberg, Daniel Reis;
Pinheiro, Rafael Soares Nunes;
Silva Neto, Amadeo Batista da;
Rocha-Santos, Vinicius;
Alves, Venâncio Avancini Ferreira;
Carneiro-DAlbuquerque, Luiz;
Andraus, Wellington.
Purpose: Gene expressions of vascular Endothelial Growth Factor Alpha (VEGFa), Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B cells (NFkB) and cytokines could be useful for identifying potential therapeutic targets to alleviate ischemia-reperfusion injury after liver transplantation. Cytokine g...
A utilização indiscriminada de cigarros eletrônicos (e-cigs) já representa um problema de saúde pública mundial e pouco se sabe quanto aos efeitos de seu uso sobre a saúde bucal. O objetivo deste trabalho foi avaliar o efeito do uso do e-cig na saliva e na mucosa bucal de seus usuários. Foram for...
A toxoplasmose é uma zoonose cosmopolita e quando a infecção ocorre durante a gravidez (toxoplasmose gestacional) o parasita pode atravessar a placenta, causando a forma congênita, e causar danos graves. Investigar como os microRNAs regulam a infecção pode oferecer informações valiosas sobre sua ...
Clausena excavata is a famous folklore medicinal plant in Asian region that is being used for the treatment of different disorders. This study investigated the cytotoxic effects of leaf extracts via MTT assay, as well as the in vitro apoptotic activities of the ethyl acetate C. excavata leaf extract (E...
Linfoma de Burkitt/tratamiento farmacológico,
Clausena/química,
Apoptosis/efectos de los fármacos,
Línea Celular Tumoral/efectos de los fármacos,
Extractos Vegetales/uso terapéutico,
Plantas Medicinales,
Extractos Vegetales/química,
Extractos Vegetales/farmacología,
Acetatos,
Supervivencia Celular/efectos de los fármacos,
Reacción en Cadena de la Polimerasa,
Expresión Génica,
Anexina A5,
Proteína X Asociada a bcl-2,
Apoptosis/genética,
Fitoquímicos/análisis,
Concentración 50 Inhibidora,
Fluoresceína-5-Isotiocianato
SUMMARY: Obesity is commonly associated with chronic tissue inflammation and skeletal muscle dysfunction. The study aimed to investigate the effects of High-Intensity Interval training (HIIT) on myokines and endoplasmic reticulum (ER) stress of diet- induced obese (DIO) mice. Three-month-old C57BL/6 male...
INTRODUCTION: Gastric cancer (GC) is the fifth most diagnosed neoplasia and the third leading cause of cancer-related deaths. A substantial number of patients exhibit an advanced GC stage once diagnosed. Therefore, the search for biomarkers contributes to the improvement and development of therapies. OBJ...
