Results: 9

Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice

Abstract INTRODUCTION: We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers. METHODS: We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (...

Histopathologic aspects of experimental cysticercosis and in situ cytokines profile in C57BL/6 mice

Arq. neuropsiquiatr; 76 (5), 2018
ABSTRACT Neurocysticercosis (NCC) is one of the parasitic infections that most affects the central nervous system. The knowledge regarding its immunopathogenesis and pathophysiology needs broadening. Taenia crassiceps cysticerci are used as the NCC experimental model. The aim of this work was to describe...

Social conditions and immune response in human immunodeficiency virus-seropositive pregnant women: a cross-sectional study in Brazil

Abstract INTRODUCTION The functioning of the immune system during pregnancy is altered in both human immunodeficiency virus (HIV)-infected and uninfected women. Unfavorable socioeconomic conditions have been indicative of higher morbidity and mortality and worsening of the immune system. The aim of thi...

Relationships of interleukin-10 with the regulatory T cell ratio and prognosis of cervical cancer patients

Clinics; 73 (), 2018
OBJECTIVE: This study investigated serum interleukin-10 (IL-10) levels, changes in peripheral blood CD4+CD25+ regulatory T cell (PBCDT) ratios, and the prognosis of cervical cancer (CC) patients. METHODS: Seventy patients with CC composed the observation group, and 70 healthy subjects composed the contr...

Humoral and cellular immune response of mice challenged with Yersinia pestis antigenic preparations

Braz. j. infect. dis; 21 (6), 2017
ABSTRACT Objectives: The plague, which is an infectious disease caused by Yersinia pestis, still threatens many populations in several countries. The worldwide increase in human plague cases and the potential use of the bacteria as a biological weapon reinforce the need to study the immunity that is ind...

The role of regulatory T cells, interleukin-10 and in vivo scintigraphy in autoimmune and idiopathic diseases - Therapeutic perspectives and prognosis

Summary Previous studies have demonstrated the expression of the CD25 marker on the surface of naturally occurring T cells (Tregs) of mice, which have a self-reactive cellular profile. Recently, expression of other markers that aid in the identification of these cells has been detected in lymphocyte subt...

IL-6, TNF-α, IL-10, and nutritional status in pediatric patients with biliary atresia

J. pediatr. (Rio J.); 93 (5), 2017
Abstract Objectives: The objective of the present study is to evaluate whether IL-6, TNF-α, IL-10 are associated with nutritional status in patients with cirrhosis secondary to biliary atresia and compare to healthy controls. Methods: The parameters used for nutritional assessment were the standar...

Toll-like receptor agonists Porphyromonas gingivalis LPS and CpG differentially regulate IL-10 competency and frequencies of mouse B10 cells

J. appl. oral sci; 25 (1), 2017
Abstract IL-10 expressing regulatory B cells (B10) play a key role in immune system balance by limiting excessive inflammatory responses. Effects of toll-like receptor signaling and co-stimulatory molecules on B10 activity during innate and adaptive immune responses are not fully understood. Objective ...

La interleucina 10 en enfermedades reumáticas autoinmunes
The interleukin 10 in autoimmunity rheumatic diseases

Rev. mex. reumatol; 11 (2), 1996
Muchas enfermedades reumáticas autoinmunes se caracterizan por hiperreactividad de sus linfocitos B que resulta en hipergammaglobulinemia y emergencia de autoanticuerpos. Recientemente se ha demostrado que la IL-10 es uno de los más potentes activadores de los linfocitos B. Induce en ellos proliferaci...