BACKGROUND: Two new SNPs have been recently associated to Alzheimer’s disease in African American populations: FCGRIIB rs1050501 C/T, and PILRA rs1859788 A/G. The risk of Alzheimer’s disease in FCGRIIB C and PILRA A allele carriers is three times higher than in non-carriers. However, the association ...
Introducción. El tacrolimus es un medicamento inmunosupresor ampliamente usado en trasplante hepático, que presenta una gran variabilidad interindividual la cual se considera asociada a la frecuencia de polimorfismos de CYP3A5 y MDR-1. El objetivo de este estudio fue evaluar la frecuencia de los polimo...
Introduction: Mycoplasma genitalium is a bacterium associated with sexually transmitted infections that can cause urethritis in men and complications in women, including preterm birth. Increasing macrolide resistance in M. genitalium poses challenges to treatment efficacy. Objective: To present a case of...
Abstract Several reasons may underlie the dramatic increase in type2 diabetes mellitus. One of these reasons is the genetic basis and variations. Vitamin D receptor polymorphisms are associated with different diseases such as rheumatoid arthritis and diabetes. The aim of this study is to investigate the ...
Background: The relationship between viral infections and host factors holds high hopes for identifying the role of Interferon Lambda 3 (IFNL3) and Interleukin 6 (IL-6) polymorphisms in the development of Chronic Liver Disease (CLD) in patients infected with hepatitis Delta virus (HDV) in the Western Bra...
Aim: This study aimed to investigate the occurrence of enamelin gene (ENAM) single nucleotide polymorphisms (SNP) and ENAM polymorphism association with dental anomalies (DA) in individuals with unilateral or bilateral cleft lip and palate (CLP). Methods: Saliva samples were collected from 147 individual...
Introduction. Vitamin D is required for bone and mineral metabolism and participates in the regulation of the immune response. It is also linked to several chronic diseases and conditions, usually in populations of European descent. Brazil presents a high prevalence of vitamin D deficiency and insufficie...
Se ha sugerido que el haplotipo rs3749474T/rs4864548A del gen CLOCK aumentaría el riesgo de obesidad, pero se desconoce el patrón de variabilidad poblacional de estos alelos y del haplotipo. El objetivo de este estudio es determinar el nivel de ligamiento entre los alelos de riesgo rs3749474T y rs48645...
Celis-Morales, Carlos;
Villagrán, Marcelo;
Mardones, Lorena;
Martínez-Sanguinetti, María Adela;
Leiva-Ordoñez, Ana María;
Carrasco-Marín, Fernanda;
Ulloa, Natalia;
Martorell, Miquel;
Lasserre-Laso, Nicole;
Díaz-Martinez, Ximena;
Cigarroa, Igor;
Concha-Cisternas, Yeny;
Troncoso-Pantoja, Claudia;
Lanuza, Fabian;
Vásquez-Gómez, Jaime;
Parra-Soto, Solange;
Petermann-Rocha, Fanny.
ANTECEDENTES: Tanto el gen FTO (Fat-mass and obesity-associated-gene) y el tiempo sedente se asocian a obesidad, sin embargo, se desconoce si el tiempo sedente puede modificar la predisposición genética a la obesidad. Por ende, el objetivo de este estudio fue investigar si la asociación entre el polim...
Adiposidad/genética,
Dioxigenasa FTO Dependiente de Alfa-Cetoglutarato/genética,
Índice de Masa Corporal,
Chile,
Estudios Transversales,
Predisposición Genética a la Enfermedad/genética,
Genotipo,
Obesidad/genética,
Polimorfismo de Nucleótido Simple/genética,
Factores de Riesgo,
Conducta Sedentaria,
Circunferencia de la Cintura/genética
