Sacarlal, Jahit;
Aponte, John J;
Aide, Pedro;
Mandomando, Inácio;
Bassat, Quique;
Guinovart, Caterina;
Leach, Amanda;
Milman, Jessica;
Macete, Eusebio;
Espasa, Mateu;
Ofori-Anyinam, Opokua;
Thonnard, Joelle;
Corachan, Sabine;
Dubois, Marie-Claude;
Lievens, Marc;
Dubovsky, Filip;
Ballou, W Ripley;
Cohen, Joe;
Alonso, Pedro L.
RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on the Plasmodium falciparum circumsporozoite surface antigen and is currently the most advanced malaria vaccine candidate in development. A proof of concept phase IIb trial of the RTS,S/AS02A in Mozambican children aged 1-4 years determined a vac...
Malaria Vaccines/adverse effects,
Malaria, Falciparum/prevention & control,
Mozambique/epidemiology,
Child, Preschool,
Double-Blind Method,
Malaria Vaccines/administration & dosage,
Malaria, Falciparum/immunology,
Malaria, Falciparum/epidemiology
Background: The roll out of various public health programmes involving mass administration of medicines calls for the deployment of responsive pharmacovigilance systems to permit identification of signals of rare or even common adverse reactions. In developing countries in Africa, these systems are mostl...
Aponte , john J;
Aide, pedro;
Renom, montse;
Mandomando, Inacio;
Bassat, quique;
Sacarlal, jahit;
Manaca, nelia;
Lafuente, sarah;
Barbosa, arnoldo;
Leach, amanda;
Vekemans , johan;
Lievens, marc;
Sigauque, betuel;
Dubois, marie-claude;
Demoitié, marie ange;
Sillman, marla;
McNeil, john G;
Savarese, barbara;
Macete, eusebio;
Cohen, joe;
Ballou, W ripley;
Alonso, pedro L.
Background: Malaria remains a leading global health problem that requires the improved use of existing interventions and the accelerated development of new control methods. We aimed to assess the safety, immunogenicity, and initial efficacy of the malaria vaccine RTS,S/AS02D in infants in Africa. Methods...
Mandomando, inácio;
Espasa, mateu;
Vallès, xavier;
Sigaúque, betuel;
Sanz, sergi;
Sacarlal, jahit;
Macete, eusébio;
Abacassamo, fátima;
Ruiz, joaquim;
Gascon, joaquim;
Kotloff, karen L;
Levine, myron.
Rectal swabs were collected from 1354 children <5 years of age with diarrhea attending Manhiça District Hospital and from 227 healthy community controls. Shigellosis incidence was high among children aged 12-47 months (488.4/10(5) child-years at risk). Fever and dysentery were prominent clinical finding...
Diarrhea/epidemiology,
Diarrhea/microbiology,
Dysentery, Bacillary/epidemiology,
Dysentery, Bacillary/microbiology,
Dysentery, Bacillary/physiopathology,
Shigella/classification,
Shigella/isolation & purification,
Mozambique/epidemiology
Menendez, clara;
Schellenberg, david;
Macete, eusebio;
Aide, pedro;
Kahigwa, elizeus;
Sanz, sergi;
Aponte, john J;
Sacarlal, jahit;
Mshinda, hassan;
Tanner, marcel;
Alonso, pedro L.
Background: Intermittent preventive treatment (IPTi) with sulphadoxine-pyrimethamine (SP) in infants resulted in different estimates of clinical malaria protection in two trials that used the same protocol in Ifakara, Tanzania, and Manhiça, Mozambique. Understanding the reasons for the discrepant result...
Segundo a Organização Mundial da Saúde (OMS), a Saúde é «um estado de completo
bem estar físico, mental e social, e não somente ausência de doença ou de enfermidade».
2. A Saúde é um bem precioso que é necessário promover, preservar, manter e melhorar. O
Artigo 89 da Constituição da Rep...
Moçambique encontra-se situado na costa do sudeste africano e faz fronteira com a Tanzania a Norte, o Malawi, Zâmbia, Zimbabwe a Este e África do Sul e Swazilândia a Sul. É banhado pelo Oceano Índico a Oeste que se estende ao longo da costa com cerca de 2.470 quilómetros. É uma República, indepe...
Health Information Systems,
Cause of Death,
Censuses,
Health,
Health Information Management,
Mozambique,
Research Report,
Activities of Daily Living,
Family Characteristics,
Morbidity,
Birth Registration
The aim of this study was to assess the effect of transmission on the outcome of treatment
of urinary schistosomiasis given in two different transmission seasons (high and low)
among schoolchildren in the urban and peri-urban areas of Matola and Maputo, southern
Mozambique. The results of this study are ...
A pancreatite aguda é uma doença inflamatória do pâncreas caracterizada por
intensa necrose pancreática e efeitos sistêmicos secundários como lesão pulmonar, os quais
são a principal causa da mortalidade observada nessa doença. Há evidências de que as
fosfolipases A2 (PLA2) têm um importante...
Pancreatitis, Acute Necrotizing,
Phospholipases A,
Blood Proteins,
Pancreatitis, Acute Necrotizing,
Inflammation/mortality,
Pancreas,
Necrosis/mortality,
Necrosis/drug therapy,
Necrosis/pathology,
Hemachatus,
Mozambique
