Resultados: 10

Emergence of bedaquiline-resistant tuberculosis and of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains with rpoB Ile491Phe mutation not detected by Xpert MTB/RIF in Mozambique: a retrospective observational study

Lancet, Infect. dis.; 12 (23), 2023
Background In 2021, an estimated 4800 people developed rifampicin-resistant tuberculosis in Mozambique, 75% of which went undiagnosed. Detailed molecular data on rifampicin-resistant and multidrug-resistant (MDR) tuberculosis are not available. Here, we aimed at gaining precise data on the determinants o...

Evaluation of the multidrug-resistant tuberculosis surveillance system in Maputo City, Mozambique in the period 2017-2018

Pan Afr. med. j; 41 (), 2022
Introduction: multidrug-resistant tuberculosis (MDR-TB) remains a public health problem worldwide. In Mozambique, cases of MDR-TB have increased annually. In 2018, 1,206 cases were reported, as compared to 943 cases in 2017. The aim of this study was to assess the surveillance system for multidrug-resist...

Adaptation of WHO's generic tuberculosis patient cost instrument for a longitudinal study in Africa

Global health action; 14 (1), 2021
The WHO developed a generic 'TB patient cost survey' tool and a standardized approach to assess the direct and indirect costs of TB incurred by patients and their households, estimate the proportion of patients experiencing catastrophic costs, and measure the impact of interventions to reduce patient cos...

Manual de manejo Clínico e programático da tuberculose multirresistente
Clinical and programmatic management manual for multidrug-resistant tuberculosis

O surgimento de resistência aos fármacos usados para tratar a tuberculose (TB), particularmente a Tuberculose Multirresistente (TB-MR), tornou-se um problema de saúde pública em vários países e, um sério obstáculo na luta contra Tuberculose, razão pela qual a OMS recomenda desde o ano 2000 uma a...

Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries

Infect. gent. evol; 72 (), 2019
Tuberculosis (TB) remains a major health problem within the Community of Portuguese Language Speaking Countries (CPLP). Despite the marked variation in TB incidence across its member-states and continued human migratory flux between countries, a considerable gap in the knowledge on the Mycobacterium tube...

TB sequel: incidence, pathogenesis and risk factors of long-term medical and social sequelae of pulmonary TB - a study protocol

BMC pulm. med; 19 (1), 2019
Background: Up to fifty percent of microbiologically cured tuberculosis (TB) patients may be left with permanent, moderate or severe pulmonary function impairment. Very few studies have systematically examined pulmonary outcomes in patients to understand the pathophysiologic basis and long-term socio-eco...

Análise das políticas de controlo da tuberculose e do perfil epidemiológico da infecção em Moçambique (2009-2017)
Analysing tuberculosis control policies and the epidemiological profile of the infection in Mozambique (2009-2017)

A epidemia da tuberculose em Moçambique tem sido influenciada consideravelmente por factores como as condições económicas, incluindo a pobreza e o desemprego, as condições ambientais, incluindo bairros urbanos superlotados, a epidemia de VIH, as condições sociais, incluindo as migrações por tra...

Perfil de sensibilidade dos isolados de Mycobacterium tuberculosis de pacientes com tuberculose e coinfectados TB/HIV na cidade da Beira, Sofala, Moçambique

A tuberculose (TB) é uma doença infecciosa que ameaça a humanidade há séculos. Recentemente grandes avanços foram conseguidos no combate à tuberculose, entretanto a resistência bacilar e a coinfecção pelo Vírus de Imunodeficiência Humana (HIV) persistem como os principais desafios dos program...

Avaliação da resistência a pirazinamida em estirpes de mycobacterium tuberculosis provenientes de pacientes atendidas na área de saúde de Mavalane

A Pirazinamida (PZA) é um medicamento com acção antituberculoso, bactericida efectivo no tratamento da tuberculose (TB). A PZA é convertida a àcido pirazinóico através da enzima pirazinamidade (Pzase) codificada pelo gene pneA do Muycobaterium tuberculosis.......

Mycobacterium tuberculosis Beijing genotype is associated with HIV infection in Mozambique

PLos ONE; 7 (9), 2012
The Beijing genotype is a lineage of Mycobacterium tuberculosis that is distributed worldwide and responsible for large epidemics, associated with multidrug-resistance. However, its distribution in Africa is less understood due to the lack of data. Our aim was to investigate the prevalence and possible t...