Resultados: 11

Genetic characterisation of south african and mozambican bovine rotaviruses reveals a typical bovine-like artiodactyl constellation derived through multiple reassortment events

PloS pathog; 20 (2), 2022
This study presents whole genomes of seven bovine rotavirus strains from South Africa and Mozambique. Double-stranded RNA, extracted from stool samples without prior adaptation to cell culture, was used to synthesise cDNA using a self-annealing anchor primer ligated to dsRNA and random hexamers. The cDNA...

Frequencia e caracterização dos genótipos de rotavirus do grupo A em crianças de 0 a 59 meses de idade, atendidas com diarreeia aguda na pediatria do Hospital Central de Nampula, 2015

A doença diarreica na infância constitui um importante problema de saúde pública em Moçambique. A infecção pelo Rotavirus é a uma das causas mais comum de diarreia aguda grave a nível mundial, sendo a diarreia terceira causa de morbi-mortalidade infantil na maioria d...

Rotavirus a strains obtained from children with acute gastroenteritis in mozambique, 2012-2013: g and p genotypes and phylogenetic analysis of vp7 and partial vp4 genes

Arch. virol; 163 (1), 2018
In Mozambique rotavirus (RV) was shown to be the greatest cause of acute diarrhoea in infants from 0 to 11 months, and in 2015, national rotavirus vaccination was introduced. As with other developing countries, there is very limited active strain characterisation. Rotavirus positive clinical specimens, c...

Perfil de sensibilidade dos isolados de Mycobacterium tuberculosis de pacientes com tuberculose e coinfectados TB/HIV na cidade da Beira, Sofala, Moçambique

A tuberculose (TB) é uma doença infecciosa que ameaça a humanidade há séculos. Recentemente grandes avanços foram conseguidos no combate à tuberculose, entretanto a resistência bacilar e a coinfecção pelo Vírus de Imunodeficiência Humana (HIV) persistem como os principais desafios dos program...

Determinants of virological failure and antiretroviral drug resistance in Mozambique

J. antimicrob. chemother; 70 (9), 2015
Objectives: The objective of this study was to inform public health actions to limit first-line ART failure and HIV drug resistance in Mozambique. Methods: This was a cross-sectional study. HIV-1-infected adults on first-line ART for at least 1 year attending routine visits in the Manhiça District Hospi...

Trends in Prevalence of HIV-1 Drug Resistance in a Public Clinic in Maputo, Mozambique

PLos ONE; 10 (7), 2015
Background: An observational study was conducted in Maputo, Mozambique, to investigate trends in prevalence of HIV drug resistance (HIVDR) in antiretroviral (ART) naïve subjects initiating highly active antiretroviral treatment (HAART). Methodology/principal findings: To evaluate the pattern of drug res...

Genetic analysis and natural polymorphisms in HIV-1 gp41 isolates from Maputo City, Mozambique

AIDS res. hum. retrovir; 30 (6), 2014
Enfuvirtide was the first fusion inhibitor approved by the Food and Drug Administration (FDA) in 2003 for HIV-1 infection in treatment-experienced patient. It is the first approved antiviral agent to attack the HIV life cycle in its early stages. For HIV fusion to occur, the HR1 and HR2 domains in the gp...

Genetic Analysis and Natural Polymorphisms in HIV-1 gp41 Isolates from Maputo City, Mozambique

AIDS res. hum. retrovir; 30 (6), 2013
Enfuvirtide was the first fusion inhibitor approved by the Food and Drug Administration (FDA) in 2003 for HIV-1 infection in treatment-experienced patient. It is the first approved antiviral agent to attack the HIV life cycle in its early stages. For HIV fusion to occur, the HR1 and HR2 domains in the gp...

MLVA based classification of Mycobacterium tuberculosis complex lineages for a robust phylogeographic snapshot of its worldwide molecular diversity

PLos ONE; 7 (9), 2012
Multiple-locus variable-number tandem repeat analysis (MLVA) is useful to establish transmission routes and sources of infections for various microorganisms including Mycobacterium tuberculosis complex (MTC). The recently released SITVITWEB database contains 12-loci Mycobacterial Interspersed Repetitive ...

Estando de polimorfismos dos genes pklr e vdr na população de moçambique

As doenças infecciosas constituem um dos principais problemas de saúde no continente Africano especialmente na África sub-Sahariana, da qual Moçambique faz parte. A participação de factores genéticos na susceptibilidade dos humanos as doenças infecciosas é um facto. A identificação de marcador...